Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium.
Daniele Campa
(1)
,
Alessandro Martino
(1)
,
Juan Sainz
(1)
,
Gabriele Buda
(2)
,
Krzysztof Jamroziak
(3)
,
Niels Weinhold
(1)
,
Rui Manuel Vieira Reis
(1)
,
Ramón García-Sanz
(4, 5)
,
Manuel Jurado
(1)
,
Rafael Ríos
(1)
,
Zofia Szemraj-Rogucka
(3)
,
Herlander Marques
(1)
,
Fabienne Lesueur
(6)
,
Peter Bugert
(7)
,
Victor Moreno
(8, 9)
,
Janusz Szemraj
(1)
,
Enrico Orciuolo
(1, 2)
,
Federica Gemignani
(1)
,
Anna Maria Rossi
(1)
,
Charles Dumontet
(10)
,
Mario Petrini
(2)
,
Hartmut Goldschmidt
(11, 12)
,
Stefano Landi
(1)
,
Federico Canzian
(1)
1
Department of Cancer Epidemiology
2 Department of Oncology, Transplants and Advanced Technologies, Section of Hematology
3 Department of Hematology
4 Haematology Department
5 Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
6 Section Génétique - Groupe Prédispositions génétiques au cancer
7 Medical Faculty of Mannheim, Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden-Württemberg-Hessen
8 Biomedical Research Centre Network for Rare Diseases
9 Biomarkers and Susceptibility Unit
10 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
11 Department of Internal Medicine V
12 NCTD - National Center for Tumor Diseases
2 Department of Oncology, Transplants and Advanced Technologies, Section of Hematology
3 Department of Hematology
4 Haematology Department
5 Centro de Investigación del Cáncer-IBMCC (USAL-CSIC)
6 Section Génétique - Groupe Prédispositions génétiques au cancer
7 Medical Faculty of Mannheim, Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden-Württemberg-Hessen
8 Biomedical Research Centre Network for Rare Diseases
9 Biomarkers and Susceptibility Unit
10 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
11 Department of Internal Medicine V
12 NCTD - National Center for Tumor Diseases
Ramón García-Sanz
- Fonction : Auteur
- PersonId : 763389
- ORCID : 0000-0003-4120-2787
Fabienne Lesueur
- Fonction : Auteur
- PersonId : 766610
- ORCID : 0000-0001-7404-4549
- IdRef : 165329939
Federica Gemignani
- Fonction : Auteur
- PersonId : 771791
- ORCID : 0000-0003-1297-0701
Hartmut Goldschmidt
- Fonction : Auteur
- PersonId : 757643
- ORCID : 0000-0003-0961-0035
Federico Canzian
- Fonction : Auteur
- PersonId : 763126
- ORCID : 0000-0002-4261-4583
- IdRef : 18925243X
Résumé
Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0*0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.