Experimental Measurement of Human Oocyte Mechanical Properties on a Micro and Nanoforce Sensing Platform Based on Magnetic Springs.

Joël Abadie (1) , Christophe Roux (2) , Emmanuel Piat (1) , C. Filiatre (3) , Caroline Amiot (2)

1 FEMTO-ST - Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174)
2 RIGHT - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
3 UTINAM - Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213)

This article presents a new micro and nanoforce sensor used to perform a mechanical characterisation of human oocytes. This device is based on the use of low-sti_ness magnetic springs. The oocytes to be characterised are placed on a force-sensitive platform. A manipulator equipped with a standard micropipette is used to mechanically compress the oocyte. Some complete \force-compression length" curves associated with mechanical load-unload cycles are given. These curves show the linear, the non-linear and also the plastic mechanical behaviour of the oocytes. These characterisations must be considered as a preliminary result which illustrates that the mechanical variability and the mechanical evolution of human oocytes during their maturation process can be observed with a force sensor based on magnetic springs.

Domaines: Micro et nanotechnologies/Microélectronique

Joël Abadie, Christophe Roux, Emmanuel Piat, C. Filiatre, Caroline Amiot. Experimental Measurement of Human Oocyte Mechanical Properties on a Micro and Nanoforce Sensing Platform Based on Magnetic Springs.. Sensors and Actuators B: Chemical, 2014, 190, pp.429-438. ⟨10.1016/j.snb.2013.08.042⟩. ⟨hal-01002533⟩