%0 Journal Article
%T Encapsulation of complementary model drugs in spray-dried nanostructured materials
%+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM)
%+ Laboratoire Charles Coulomb (L2C)
%A Fatnassi, Mohamed
%A Tourné-Péteilh, Corine
%A Peralta, Pradial
%A Cacciaguerra, Thomas
%A Dieudonné, Philippe
%A Devoisselle, Jean-Marie
%A Alonso, Bruno
%Z Institut Carnot CED2
%< avec comité de lecture
%@ 0928-0707
%J Journal of Sol-Gel Science and Technology
%I Springer Verlag
%V 68
%N 2
%P 307-316
%8 2013-11
%D 2013
%R 10.1007/s10971-013-3170-y
%K Acetaminophen
%K Ibuprofen
%K Drug
%K delivery systems
%K Self-assembly
%K Sol-gel materials
%K Spray-drying
%Z Chemical Sciences/Material chemistryJournal articles
%X Two model drugs of different physico-chemical and pharmaceutical properties (ibuprofen, acetaminophen) have been incorporated together or separately in silicabased microspheres using sol-gel and spray-drying processes. A variable amount of a neutral surfactant Brij-56 has also been added. The properties of the microspheres vary significantly depending on their composition. Three kinds of texture are identified: (1) silica containing spheroid nano-domains (formed by ibuprofen; diameters between 20 and 100 nm), (2) silica containing worm-like mesophases (formed by Brij-56 and both model drugs, typical correlation distances *6 nm), (3) silica intimately mixed with the drug (acetaminophen) without visible phase-separation. The kinetics of drug release in simulated intestinal fluid strongly depend on these textures. The association of ibuprofen and acetaminophen in a single type of microsphere and without surfactant favours a concomitant release. Possible mechanisms of materials' formation are discussed.
%G English
%L hal-00921864
%U https://hal.science/hal-00921864
%~ CNRS
%~ UNIV-MONTP1
%~ UNIV-MONTP2
%~ ENSC-MONTPELLIER
%~ ICG
%~ L2C
%~ INC-CNRS
%~ MIPS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UM1-UM2
%~ UM-2015-2021
%~ TEST2-HALCNRS