Directed Studies Towards The Total Synthesis of (+)-13-Deoxytedanolide: Simple and Convenient Synthesis of C8-C16 Fragment

Sébastien Meiries (1) , Alexandra Bartoli (1) , Mélanie Decostanzi (1) , Jean-Luc Parrain (1) , Laurent Commeiras (1)

1 STeRéO

A straightforward synthesis of the enantioenriched C8-C16 south part of (+)-13-deoxytedanolide has been reported. The strength of this approach relies on the preparation of similar functionalized fragments via the transformation of a unique dihydrofuran building block through a 1,2-metallate rearrangement.

Mots clés: Natural product; macrolactone; dihydrofuran

Domaines: Chimie organique

Sébastien Meiries, Alexandra Bartoli, Mélanie Decostanzi, Jean-Luc Parrain, Laurent Commeiras. Directed Studies Towards The Total Synthesis of (+)-13-Deoxytedanolide: Simple and Convenient Synthesis of C8-C16 Fragment. Organic & Biomolecular Chemistry, 2013, 11, pp.4882-4890. ⟨10.1039/c3ob40674a⟩. ⟨hal-00861650⟩