a multi-element MR-guided interstitial ultrasound probe for the thermal ablation of brain tumors: initial testing in a canine model
Résumé
In this work, an interstitial ultrasound probe, designed for performing thermal ablation of brain tumors under MR guidance, was tested in a canine model. The ultrasound device consisted of a multi-element, interstitial device operating at intensities of 20-30 W/cm$^2$ and a frequency of 6 MHz. The device was used to perform heating in the brains of 3 healthy Beagle canines. Treatments lasted from 4-6 minutes and were monitored using a 1.5T magnetic resonance imaging (MRI) system to obtain 3D real-time temperature maps. Custom software displayed temperature and thermal dose during exposures. After treatment, contrast-enhanced MR images were obtained and compared with predicted regions of thermal necrosis from real-time temperature maps. Temperatures of greater than 55°C were induced in vivo during heating and regions of ablation of 1-2 cm$^3$ were visible on post-treatment MR images. Regions of damage on post-treatment images compared well with predicted regions of thermal necrosis using MR thermometry. Interstitial ultrasound applicators, operated under MR guidance, may be a viable, minimally invasive treatment for the thermal ablation of brain tumors. Work supported by the French Ministry of Research, OSEO and CarThéra
Domaines
Acoustique [physics.class-ph]
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