Metabolic changes in the tissues of experimental animals in the conditions of high level noise action

Magdalina Melkonyan , Lilit Hunanyan , Gayane Zaqaryan , Ashchen Manukyan , Lilit Ayvazyan

The goal of this investigation is to study the anti- and prooxidants balance in tissues in acoustic stress conditions, as we take into account great amount of real facts concerning it’s role in the pathogenesis of many diseases. The experimental animals (white mongrel rats) underwent 91 dBA noise level influence with maximum energy in the range of medium and high frequency. Intensity of lipid peroxidation and protein oxidation, the changes in the content of alfa-tocopherol, activity of antioxidant enzymes in different tissues have been studied. Simultaneously structural components of biomembranes and structural and immunological changes in the immunogenesis organs: thymus, spleen and lymph nodes were studied as well. The revealed shifts in the thymus, spleen and lymphatic nodes after the 6 hours influence of noise, are, in our opinion, transient, since the whole syndrome corresponds to a relatively late stage of the stress syndrome tension phase. The data obtained revealed significant changes in the intensity of lipid peroxidation,alpha-tocopherol content in all studied tissues, in the content of phospholipid glycerides in the brain mitochondrial and erythrocyte membranes, depending on both the sex of animals and the duration of noise action.

Mots clés: noise; lipid peroxidation; antioxidants; biomembranes

Domaines: Acoustique [physics.class-ph]

Magdalina Melkonyan, Lilit Hunanyan, Gayane Zaqaryan, Ashchen Manukyan, Lilit Ayvazyan. Metabolic changes in the tissues of experimental animals in the conditions of high level noise action. Acoustics 2012, Apr 2012, Nantes, France. ⟨hal-00810569⟩