%0 Journal Article
%T Development and characterization of ultra-porous silica films made by the sol-gel method. Application to biosensing.
%+ Laboratoire Charles Coulomb (L2C)
%+ Laboratoire de Bioingénierie et NanoSciences (LBN)
%A Desfours, Caroline
%A Calas-Etienne, Sylvie
%A Horvath, Robert
%A Martin, Marta
%A Gergely, Csilla
%A Cuisinier, Frederic J. G.
%A Etienne, Pascal
%< avec comité de lecture
%@ 0947-8396
%J Applied physics. A, Materials science & processing
%I Springer Verlag
%P DOI 10.1007/s00339-013-7662-y
%8 2013-03-22
%D 2013
%R 10.1007/s00339-013-7662-y
%Z Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]Journal articles
%X The aim of this work is to demonstrate the sensing ability of reverse-symmetry waveguides to investigate adsorption of casein and build-up of poly-L-lysine mediated casein multilayers. A first part of this study is dedicated to the elaboration and characterization of ultra-porous thin films with very low refractive indices by an appropriate sol-gel method. This will form the basis of our planar optical sensors. Optical waveguide light mode spectroscopy is a real-time and sensitive method to study protein adsorption kinetics and lipid bilayers. We used it to test the obtained waveguides for in-situ monitoring of biomolecule adsorption. As a result, significant changes in the incoupling peak position were observed during the layer-by-layer adsorption. Finally, refractive index and thickness of the adsorbed layers were established.
%G English
%L hal-00804662
%U https://hal.science/hal-00804662
%~ CNRS
%~ UNIV-MONTP1
%~ L2C
%~ MIPS
%~ BS
%~ UNIV-MONTPELLIER
%~ LBN
%~ UM1-UM2
%~ UM-2015-2021