%0 Journal Article
%T Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
%+ Institut de Génomique Fonctionnelle (IGF)
%+ Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc)
%+ Laboratoire Charles Coulomb (L2C)
%+ Cisbio Bioassays
%+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
%A Schaeffer, Marie
%A Langlet, Fanny
%A Lafont, Chrystel
%A Molino, François
%A Hodson, David J
%A Roux, Thomas
%A Lamarque, Laurent
%A Verdié, Pascal
%A Bourrier, Emmanuel
%A Dehouck, Bénédicte
%A Banères, Jean-Louis
%A Martinez, Jean
%A Méry, Pierre-François
%A Marie, Jacky
%A Trinquet, Eric
%A Fehrentz, Jean-Alain
%A Prévot, Vincent
%A Mollard, Patrice
%< avec comité de lecture
%Z L2C:13-031
%@ 0027-8424
%J Proceedings of the National Academy of Sciences of the United States of America
%I National Academy of Sciences
%V 110
%N 4
%P 1512-7
%8 2013-01-22
%D 2013
%R 10.1073/pnas.1212137110
%M 23297228
%Z Computer Science [cs]/Bioinformatics [q-bio.QM]
%Z Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]Journal articles
%X To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.
%G English
%L hal-00796900
%U https://hal.science/hal-00796900
%~ CNRS
%~ UNIV-MONTP1
%~ UNIV-MONTP2
%~ ENSC-MONTPELLIER
%~ IBMM
%~ IGF
%~ L2C
%~ INC-CNRS
%~ MIPS
%~ BS
%~ CHIMIE
%~ UNIV-MONTPELLIER
%~ UNIV-LILLE
%~ UM1-UM2
%~ UM-2015-2021