PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY - A NONINVASIVE TECHNIQUE FOR THE STUDY OF OCCLUSIVE ARTERIAL LEG DISEASE AND PERIPHERAL VASODILATOR THERAPY

Denis Wahl (1) , J.P. Simon (1) , Brigitte Robin (2) , Paul Walker (3) , P. Jouanny (1) , Jean Marie Escanyé (4, 2) , F. Paille (1) , C. Schmidt (1) , François Brunotte (3) , Jacques Robert (4) , J. Schmitt (1)

1 Service de Médecine Interne et Médecine Générale [CHRU Nancy]
2 laboratoire de methodologie RMN
3 Le2i - Laboratoire Electronique, Informatique et Image [UMR6306]
4 Service de Médecine Nucléaire [CHRU Nancy]

Abstract: Using P-31 nuclear magnetic resonance spectroscopy of the calf muscle, the authors studied patients with peripheral arterial occlusive disease. They studied PCr depletion and intracellular pH during aerobic exercise in patients and controls. The phosphocreatine (PCr) index {[PCr] / ([PCr] + [Pi])} at rest was correlated with blood flow measured by plethysmography. During aerobic exercise a greater decrease in pH was obtained in patients (p < 0.03). They also studied the work necessary to reach a PCr index = 0.5 during ischemic exercise. This workload was lower in patients than in controls: 32.99 +/- 3.04 J vs 58.89 +/- 8.55 J, p < 0.05. After vasodilator therapy the workload was improved in patients: 32.99 +/- 3.04 J vs 38.85 +/- 3.54 J, p < 0.05. These results suggest that therapy resulted in improved tissue perfusion in patients.

Mots clés: HUMAN SKELETAL-MUSCLE; METABOLIC-ACTIVITY; CALF MUSCLE; P-31 NMR; INSUFFICIENCY; EXERCISE

Domaines: Imagerie médicale

Denis Wahl, J.P. Simon, Brigitte Robin, Paul Walker, P. Jouanny, et al.. PHOSPHORUS MAGNETIC-RESONANCE SPECTROSCOPY - A NONINVASIVE TECHNIQUE FOR THE STUDY OF OCCLUSIVE ARTERIAL LEG DISEASE AND PERIPHERAL VASODILATOR THERAPY. Angiology, 1994, 45 (5), pp.367-376. ⟨10.1177/000331979404500506⟩. ⟨hal-00790161⟩