Sonic aerosol therapy to target maxillary sinuses

Marc Durand (1) , Sandrine Le Guellec (2) , Jérémie Pourchez (1, 3, 4) , Francis Dubois (5) , Gérald Aubert (6) , Gilles Chantrel (7) , Laurent Vecellio (2) , Cloé Hupin (8) , Ruth de Gersem (9) , Grégory Reychler (10) , Laurent Pitance (10) , Patrice Diot (11) , François Jamar (9)

1 IFRESIS - Institut Fédératif de Recherche en Sciences et Ingénierie de la Santé
2 DTF-Aerodrug
3 CIS-ENSMSE - Centre Ingénierie et Santé
4 LINA-ENSME - Laboratoire Interdisciplinaire des Nanoparticules Aérosolisées
5 Service de Médecine Nucléaire
6 Laboratoire Antibiologie
7 DTF-Médical
8 Service ORL Cliniques Universitaires Saint Luc
9 Service de Médecine Nucléaire Cliniques Universitaires Saint Luc
10 Service Pneumologie Cliniques Universitaires Saint Luc
11 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie

Aim: Intranasal aerosol administration of drugs is widely used by ENT specialists. Although clinical evidence is still lacking, intranasal nebulization appears to be an interesting therapeutic option for local drug delivery, targeting anatomic sites beyond the nasal valve. The sonic nebulizer NL11SN associates a 100 Hertz (Hz) sound to the aerosolization to improve deposition in the nasal/paranasal sinuses. The aim of the present study was: to evaluate in vivo the influence of associating a 100 Hz sound on sinus ventilation and nasal and pulmonary aerosol deposition in normal volunteers, and; to quantify in vitro aerosol deposition in the maxillary sinuses in a plastinated head model. Material and methods: Scintigraphic analysis of 81mKr gas ventilation and of sonic aerosol (99mTc-DTPA) deposition using the NL11SN was performed in vivo in seven healthy volunteers. In parallel, NL11SN gentamicin nebulization was performed, with or without associated 100 Hz sound, in a plastinated human head model; the gross amount of gentamicin delivered to the paranasal sinuses was determined by fluorescence polarization immunoassay. Results: Associating the 100 Hz sound to 81mKr gas ensured paranasal sinus ventilation in healthy volunteers. 99mTc-DTPA particles nebulized with the NL11SN were deposited predominantly in the nasal cavities (2/3, vs 1/3 in the lungs). In vitro, the use of NL11SN in sonic mode increased gentamicin deposition threefold in the plastinated model sinuses (P < 0.002); the resulting antibiotic deposit would be sufficient to induce a local therapeutic effect. Conclusion: The NL11SN nebulizer ensured preferential nasal cavity aerosol deposition and successfully targeted the maxillary sinuses.

Mots clés: Sonic aerosol; 100 Hertz; Scintigraphy; Healthy volunteers; Plastinated head model; Nasal; Sinus; Rhinosinusitis

Domaines: Génie des procédés; Pneumologie et système respiratoire

Marc Durand, Sandrine Le Guellec, Jérémie Pourchez, Francis Dubois, Gérald Aubert, et al.. Sonic aerosol therapy to target maxillary sinuses. European Archives of Oto-Rhino-Laryngology, 2012, 129 (5), pp.244-250. ⟨10.1016/j.anorl.2011.09.002⟩. ⟨hal-00757723⟩