%0 Journal Article
%T SVSVGMKPSPRP: a broad range adhesion peptide
%+ Laboratoire Charles Coulomb (L2C)
%+ Laboratoire de Bioingénierie et NanoSciences (LBN)
%+ Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1)
%A Estephan, Elias
%A Dao, Jérome
%A Saab, Marie-Belle
%A Panayotov, Ivan
%A Martin-Fernandez, Marta
%A Larroque, Christian
%A Gergely, Csilla
%A Cuisinier, Frédéric J. G.
%A Levallois, Bernard
%< avec comité de lecture
%Z L2C:12-231
%@ 0013-5585
%J Biomedical Engineering = Biomedizinische Technik
%I De Gruyter
%P 10.1515/bmt-2011-0109
%8 2012-11-20
%D 2012
%R 10.1515/bmt-2011-0109
%Z Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]Journal articles
%X Background: A combinatorial phage display approach was previously used to evolve a 12-mer peptide (SVSVGMKP- SPRP) with the highest affinity for different semiconductor surfaces.Thediscoveryofthemultipleoccurrencesofthe SVSVGMKPSPRP sequence in an all-against-all basic local alignment search tool search of PepBank sequences was unexpected, and a Google search using the peptide sequence recovered 58 results concerning 12 patents and 16 scientific publications. The number of patent and articles indicates that the peptide is perhaps a broad range adhesion peptide. Methods: To evaluate peptide properties, we conducted a study to investigate peptide adhesion on different inor- ganic substrates by mass spectrometry and atomic force microscopy for gold, carbon nanotubes, cobalt, chrome alloy, titanium, and titanium alloy substrates. Results: Our results showed that the peptide has a great potential as a linker to functionalize metallic surfaces if specificity is not a key factor. This peptide is not specific to a particular metal surface, but it is a good linker for the functionalization of a wide range of metallic materials. Conclusion: The fact that this peptide has the potential to adsorb on a large set of inorganic surfaces suggests novel promising directions for further investigation. Affinity determination of SVSVGMKPSPRP peptide would be an important issue for eventual commercial uses.
%G English
%L hal-00755416
%U https://hal.science/hal-00755416
%~ CNRS
%~ UNIV-MONTP1
%~ L2C
%~ FNCLCC
%~ VALDAURELLE
%~ MIPS
%~ BS
%~ UNIV-MONTPELLIER
%~ IRCM
%~ LBN
%~ UM1-UM2
%~ UM-2015-2021