Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanism

Hannu Kankaanranta (1, 2) , Jouni Parkkonen (1) , Pinja Ilmarinen-Salo (1) , Mark A. Giembycz (3) , Eeva Moilanen (1)

1 Tampere University Hospital
2 Department of Respiratory Medicine
3 Faculty of Medicine

Eosinophils play a major role in asthma. One described mechanism leading to the impaired clearance of these cells from the lung is the delay in their programmed cell death (apoptosis). β-adrenoceptor agonists have been shown to prolong survival and delay apoptosis of eosinophils. The aim of the present study was to evaluate the mechanisms, especially the role of cAMP pathway, in the prolongation of human eosinophil survival by a selective β-agonist salbutamol.

Mots clés: eosinophils; apoptosis; salbutamol; cAMP

Domaines: Pneumologie et système respiratoire

Hannu Kankaanranta, Jouni Parkkonen, Pinja Ilmarinen-Salo, Mark A. Giembycz, Eeva Moilanen. Salbutamol delays human eosinophil apoptosis via a cAMP-dependent mechanism. Pulmonary Pharmacology & Therapeutics, 2011, ⟨10.1016/j.pupt.2011.03.002⟩. ⟨hal-00753952⟩