Simple Patient-Based Transmantle Pressure and Shear Estimate From Cine Phase-Contrast MRI in Cerebral Aqueduct

Gérald Bardan (1) , Franck Plouraboué (1) , Mokhtar Zagzoule (1) , Olivier Balédent (2)

1 IMFT - Institut de mécanique des fluides de Toulouse
2 CHU Amiens-Picardie

From measurements of the oscillating flux of the cerebrospinal fluid (CSF) in the aqueduct of Sylvius, we elaborate a patient-based methodology for transmantle pressure (TRP) and shear evaluation. High-resolution anatomical magnetic resonance imaging first permits a precise 3-D anatomical digitalized reconstruction of the Sylvius's aqueduct shape. From this, a very fast approximate numerical flow computation, nevertheless consistent with analytical predictions, is developed. Our approach includes the main contributions of inertial effects coming from the pulsatile flow and curvature effects associated with the aqueduct bending. Integrating the pressure along the aqueduct longitudinal center-line enables the total dynamic hydraulic admittances of the aqueduct to be evaluated, which is the pre-eminent contribution to the CSF pressure difference between the lateral ventricles and the subarachnoidal spaces also called the TRP. The application of the method to 20 healthy human patients validates the hypothesis of the proposed approach and provides a first database for normal aqueduct CSF flow. Finally, the implications of our results for modeling and evaluating intracranial cerebral pressure are discussed.

Mots clés: Aqueduct of sylvius; Cerebrospinal fluid (CSF); Electric impedance modeling; Fourier decomposition; Intracranial pressure; Pulsatile flows; Transmantle pressure (TRP)

Domaines: Traitement des images [eess.IV]; Mécanique des fluides [physics.class-ph]; Mécanique des fluides [physics.class-ph]

Gérald Bardan, Franck Plouraboué, Mokhtar Zagzoule, Olivier Balédent. Simple Patient-Based Transmantle Pressure and Shear Estimate From Cine Phase-Contrast MRI in Cerebral Aqueduct. IEEE Transactions on Biomedical Engineering, 2012, vol. 59, pp.2874-2883. ⟨10.1109/TBME.2012.2210716⟩. ⟨hal-00746487⟩