Biocompatibility of oxygen-plasma-treated polystyrene substrates

A. Vesel , M. Mozetic , M. Jaganjac , L. Milkovic , A. Cipak , N. Zarkovic

The biocompatibility of polystyrene (PS) samples has been improved by treatment with weakly ionized highly non-equilibrium oxygen plasma. Samples were exposed to plasma for 30 s for which they have received a dose of ions of 4.5 × 10 m and a neutral oxygen atom dose of 3 × 10 m. Both untreated and plasma-treated samples were tested for biocompatibility according to the same procedure. Proliferation of human mammary epithelial cells (HMECs) on samples revealed a dramatically improved biocompatibility of polystyrene treated by oxygen plasma. The HMECs were deposited on all samples and incubated for 1, 2 and 6 days. MTT test revealed about two times higher activity of cell enzymes after 48 h incubation. The activity for plasma-treated samples remained much higher than for untreated samples even after 6 days of incubation when the samples were already covered with a dense film of HMECs.

Mots clés: Physical Sciences

Domaines: Physique [physics]

A. Vesel, M. Mozetic, M. Jaganjac, L. Milkovic, A. Cipak, et al.. Biocompatibility of oxygen-plasma-treated polystyrene substrates. European Physical Journal: Applied Physics, 2011, 56 (2), pp.24024. ⟨10.1051/epjap/2011110169⟩. ⟨hal-00746215⟩