Systrip: a visual environment for the investigation of time-series data in the context of metabolic networks

Jonathan Dubois (1) , Ludovic Cottret (2) , Amine Ghozlane (1, 3) , David Auber (1, 4) , Frédéric Bringaud (5) , Patricia Thebault (1, 3) , Fabien Jourdan (2) , Romain Bourqui (1, 4)

1 LaBRI - Laboratoire Bordelais de Recherche en Informatique
2 INRA - Institut National de la Recherche Agronomique
3 CBIB - Centre de Bioinformatique de Bordeaux
4 GRAVITE - Graph Visualization and Interactive Exploration
5 CRMSB - Centre de résonance magnétique des systèmes biologiques

Technological advances in biology lead to a profusion of quantitative data, raising analytical challenges. Visual analytics is particularly well suited to address these difficulties. It helps to interactively move through the different levels of analysis and to simultaneously investigate data with different point of views. It is especially the case when dealing with biological networks that can contain hundreds of elements. In these studies biologists generally follow the same analytic process which consists in first getting an overview of the data before focussing on a few relevant subnetworks. In this article we present, Systrip, a visual environment for the analysis of time-series data in the context of biological networks. In particular we focus on the study of metabolism. Systrip gathers bioinformatics and graph theoretical algorithms that can be assembled in different ways to help biologists in their visual mining process. This framework had been used to analyse various real biological data. In this article we describe how it helped in understanding drug effects on the metabolism of the parasite of the tsetse fly causing sleeping sickness.

Mots clés: graph visualization; metabolic networks

Domaines: Autre [cs.OH]

Jonathan Dubois, Ludovic Cottret, Amine Ghozlane, David Auber, Frédéric Bringaud, et al.. Systrip: a visual environment for the investigation of time-series data in the context of metabolic networks. 16th International Conference on Information Visualization (IV'12), Jul 2012, Montpellier, France. pp.4771a204. ⟨hal-00742176⟩