Syntheses and DNA binding of new cationic porphyrin-tetrapeptide conjugates

Gábor Mező (1) , Levente Herényi (2) , Jan Habdas (3) , Zsuzsa Majer (1) , Beata Myśliwa-Kurdziel (4) , Katalin Tóth , Gabriella Csík (2)

1 ELTE - Eötvös Loránd University
2 Semmelweis University [Budapest]
3 University of Silesia in Katowice
4 Department of Plant Physiology and Biochemistry

Recently cationic porphyrin-peptide conjugates were synthesized to enhance the cellular uptake of porphyrins or deliver the peptide moiety to the close vicinity of nucleic acids. DNA binding of such compounds was not systematically studied yet.

Mots clés: cationic porphyrin; photophysical parameters; porphyrin-peptide conjugate; fluorescence spectroscopy; intercalation

Domaines: Chimie-Physique [physics.chem-ph]

Gábor Mező, Levente Herényi, Jan Habdas, Zsuzsa Majer, Beata Myśliwa-Kurdziel, et al.. Syntheses and DNA binding of new cationic porphyrin-tetrapeptide conjugates. Biophysical Chemistry, 2011, 155 (1), pp.36. ⟨10.1016/j.bpc.2011.02.007⟩. ⟨hal-00734591⟩