RITA-Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats

Thomas Nolte (1) , Susanne Rittinghausen (2) , Rupert Kellner (2) , Eberhard Karbe , Birgit Kittel (3) , Matthias Rinke , Ulrich Deschl (1)

1 Boehringer Ingelheim Pharma GmbH & Co. KG
2 Fraunhofer ITEM - Fraunhofer Institute for Toxicology and Experimental Medicine
3 NIBR - Novartis Institutes for BioMedical Research

Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors.

Mots clés: Leydig cell tumor; interstitial cell adenoma; Leydig cell adenoma; Leydig cell carcinoma; interstitial cell carcinoma; interstitial cell tumor; testis; testes; rat; rodent; carcinogenicity testing; carcinogenicity; oncogenicity; RITA; Registry of Industrial Toxicology Animal-data; historical control data

Domaines: Toxicologie

Thomas Nolte, Susanne Rittinghausen, Rupert Kellner, Eberhard Karbe, Birgit Kittel, et al.. RITA-Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats. Experimental and Toxicologic Pathology, 2011, 63 (7-8), pp.645. ⟨10.1016/j.etp.2010.05.006⟩. ⟨hal-00734584⟩