Micropatterning thermoplasmonic gold nanoarrays to manipulate cell adhesion

Min Zhu (1) , Guillaume Baffou (2) , Nikolaus Meyerbröker (3) , Julien Polleux (4)

1 Department of Molecular Medicine [Martinsreid]
2 MOSAIC - MOSAIC
3 Angewandte Physikalische Chemie, Universität Heidelberg
4 MPIB - Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry

The ability to reversibly control the interactions between the extracellular matrix (ECM) and cell surface receptors such as integrins would allow one to investigate reciprocal signaling circuits between cells and their surrounding environment. Engineering microstructured culture substrates functiona- lized with switchable molecules remains the most adopted strategy to manipulate surface adhesive properties, although these systems exhibit limited reversibility and require sophisticated preparation procedures. Here, we report a straightforward protocol to fabricate biofunctionalized micropatterned gold nanoarrays that favor one-dimensional cell migration and function as plasmonic nanostoves to physically block and orient the formation of new adhesion sites. Being reversible and not restricted spatiotemporally, thermoplasmonic approaches will open new opportunities to further study the complex connections between ECM and cells.

Mots clés: block copolymer micellar lithography; deep UV lithography; thermoplasmonics; cell adhesion; nanobiotechnology

Domaines: Optique / photonique

Min Zhu, Guillaume Baffou, Nikolaus Meyerbröker, Julien Polleux. Micropatterning thermoplasmonic gold nanoarrays to manipulate cell adhesion. ACS Nano, 2012, 6 (8), pp.7227-7233. ⟨10.1021/nn302329c⟩. ⟨hal-00728839⟩