Patient Reported Outcomes and Low-level Residual HIV-RNA in Adolescents Perinatally infected with HIV-1 after Switching to One-Pill Fixed-dose Regimen

Raffaella Rosso (1) , Antonio Di Biagio (2) , F Maggiolo , Loredana Nulvesu , Annapaola Callegaro , Lucia Taramasso (1) , Bianca Bruzzone , Claudio Viscoli (1)

1 Infectious Diseases
2 Internal Medicine and Infectious Diseases

The choice of an antiretroviral regimen can often impact on adherence, treatment satisfaction and therefore influence on clinical outcome. These concerns are particularly true in adolescents. In this setting adherence is usually affected by multifactor events and biopsychosocial factors, which connect and change over time. We evaluated the effect of a switch to a single-pill fixed-dose regimen on patient-reported outcomes, virologic and immunologic outcomes, and safety in a cohort of adolescents with perinatal HIV-1 infection. In addition we evaluated the effect on low-level residual HIV-RNA. An open-label, non-randomized study was performed: twelve adolescents with a confirmed viremia <50 copies/mL treated with lamivudine or emtricitabine, tenofovir, and efavirenz were switched to one-pill fixed-dose regimen of emtricitabine/tenofovir/efavirenz. At the end of follow-up the new regimen was associated with improvements in treatment satisfaction, HIV-symptoms, whereas adherence remained high. No immunological or virological significative changes were observed. No side effects were registered. Moreover the low-level residual HIV-RNA was <3 copie/mL in all patients. One-pill fixed-dose regimen is an added value that favours adherence, reduces HIV-symptoms, improves patients' satisfaction, and could better control of HIV-RNA in adolescents, too.

Mots clés: Life Sciences

Domaines: Santé publique et épidémiologie

Raffaella Rosso, Antonio Di Biagio, F Maggiolo, Loredana Nulvesu, Annapaola Callegaro, et al.. Patient Reported Outcomes and Low-level Residual HIV-RNA in Adolescents Perinatally infected with HIV-1 after Switching to One-Pill Fixed-dose Regimen. AIDS Care, 2011, pp.1. ⟨10.1080/09540121.2011.596511⟩. ⟨hal-00721643⟩