Isolated Cryptorchidism: No Evidence for Involvement of Genes Underlying Idiopathic Hypogonadotropic Hypogonadism

Eeva-Maria Laitinen (1, 2) , Johanna Tommiska (1, 2) , Helena E. Virtanen (3) , Heidi Oehlandt (2) , Rosanna Koivu (2) , Kirsi Vaaralahti (2, 1) , Jorma Toppari (2) , Taneli Raivio (1, 2)

1 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
2 Institute of Biomedicine/Physiology
3 Departments of Physiology and Pediatrics

► We investigated the defects in , , , , , and in 54 subjects with isolated cryptorchidism. ► Two subjects carried heterozygous mutations (Q106R and R262Q), but these changes were also present in controls with similar frequency. ► None of the subjects carried mutation(s) in , , , or . ► It is unlikely that mutations in these genes would significantly contribute to the prevalence of isolated cryptorchidism.

Mots clés: IHH; Cryptorchidism; FGFR1; GNRHR; PROK2; PROKR2; TAC3; TACR3

Domaines: Biochimie, Biologie Moléculaire

Eeva-Maria Laitinen, Johanna Tommiska, Helena E. Virtanen, Heidi Oehlandt, Rosanna Koivu, et al.. Isolated Cryptorchidism: No Evidence for Involvement of Genes Underlying Idiopathic Hypogonadotropic Hypogonadism. Molecular and Cellular Endocrinology, 2011, 341 (1-2), pp.35. ⟨10.1016/j.mce.2011.05.015⟩. ⟨hal-00719875⟩