Physical and Catalytic Properties of a Peroxidase Derived from Cytochrome C

Johannes Everse , Chyong-Jy J. Liu , Penelope W. Coates

Except for its redox properties, cytochrome c is an inert protein. However, dissociation of the bond between methionine-80 and the heme iron converts the cytochrome into a peroxidase. Dissociation is accomplished by subjecting the cytochrome to various conditions, including proteolysis and hydrogen peroxide (HO)-mediated oxidation.

Mots clés: ABTS; DTNB; DTPA; DOPA; GSH; MESNA; PBS; cytochrome c; peroxidase; Parkinson's disease; neurodegeneration; cytolysis; cellular metabolites

Domaines: Biochimie, Biologie Moléculaire

Johannes Everse, Chyong-Jy J. Liu, Penelope W. Coates. Physical and Catalytic Properties of a Peroxidase Derived from Cytochrome C. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (9), pp.1138. ⟨10.1016/j.bbadis.2011.05.003⟩. ⟨hal-00719830⟩