Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2011

Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism

L.W. Lawrence Woo
  • Fonction : Auteur
Barry V.L. Potter
  • Fonction : Auteur

Résumé

Steroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to steroids with estrogenic properties (i.e. estradiol and androstenediol) that can stimulate the growth of tumors in hormone-responsive tissues of the breast, endometrium and prostate. Hence, the action of steroid sulfatase is implicated in physiological processes and pathological conditions. It has been five years since our group last reviewed the important role of this enzyme in steroid synthesis and the progress made in the development of potent inhibitors of this important enzyme target. This timely review therefore concentrates on recent advances in steroid sulfatase research, and summarises the findings of clinical trials with Irosustat (BN83495), the only steroid sulfatase inhibitor that is being trialed in postmenopausal women with breast or endometrial cancer.
Fichier principal
Vignette du fichier
PEER_stage2_10.1016%2Fj.mce.2011.06.012.pdf (278.28 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00717913 , version 1 (14-07-2012)

Identifiants

Citer

Atul Purohit, L.W. Lawrence Woo, Barry V.L. Potter. Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism. Molecular and Cellular Endocrinology, 2011, 340 (2), pp.154. ⟨10.1016/j.mce.2011.06.012⟩. ⟨hal-00717913⟩

Collections

PEER
87 Consultations
206 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More