An inflammatory micro-environment promotes human adipocyte apoptosis

Michaela Keuper (1) , Matthias Blüher (2) , Michael R. Schön , Peter Möller (3) , Anna Dzyakanchuk , Kurt Amrein , Klaus-Michael Debatin (1) , Martin Wabitsch (1) , Pamela Fischer-Posovszky (1)

1 Department of Pediatrics and Adolescent Medicine
2 Medical Department III
3 Universität Ulm - Ulm University [Ulm, Allemagne]

Obesity-associated macrophage infiltration into adipose tissue is responsible for both local and systemic inflammation. Recent findings suggest fat cell apoptosis as an initiator of macrophage recruitment.

Mots clés: inflammation; fat cells; macrophages; apoptosis; insulin resistance

Domaines: Biochimie, Biologie Moléculaire

Michaela Keuper, Matthias Blüher, Michael R. Schön, Peter Möller, Anna Dzyakanchuk, et al.. An inflammatory micro-environment promotes human adipocyte apoptosis. Molecular and Cellular Endocrinology, 2011, ⟨10.1016/j.mce.2011.04.004⟩. ⟨hal-00708527⟩