Plant Lectins are Novel Toll-Like Receptor Agonists

John Unitt , David Hornigold

The T cell mitogen and plant glycoprotein, phytohaemagglutinin (PHA), is commonly used to stimulate peripheral blood mononuclear cell (PBMC) preparations to produce IL-2, IL-5, GM-CSF and IFN-γ and so provide an assay to detect immunosuppressants like FK506 and anti-inflammatories such as PDE IV inhibitors.

Mots clés: Toll-like receptors; Plant lectins; LPS; Phytohaemagglutinin; Reporter assay

Domaines: Pharmacologie

John Unitt, David Hornigold. Plant Lectins are Novel Toll-Like Receptor Agonists. Biochemical Pharmacology, 2011, ⟨10.1016/j.bcp.2011.03.010⟩. ⟨hal-00693837⟩