and placental inflammation in early preterm delivery

G. Ingrid J. G. Rours (1, 2) , Ronald R. Krijger (3) , Alewijn Ott (4) , Hendrina F. M. Willemse (2) , Ronald Groot (5) , Luc J. I. Zimmermann (6) , Renee F. Kornelisse (7) , Henri A. Verbrugh (2) , Roel P. Verkooijen (2)

1 Department of Paediatric Infectious Disease and Immunology
2 Department of Medical Microbiology and Infectious Diseases
3 Department of Pathology, Josephine Nefkens Institute
4 Laboratory for Infectious Diseases
5 Department of Pediatrics
6 Department of Paediatrics
7 Department of Paediatrics

may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. testing of placentas was done retrospectively using PCR. was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with versus 82/228 (36%) placentas without infection (OR 2.1, 95% CI 1.2-3.5). infection correlated with the progression ( = 0.009) and intensity ( = 0.007) of materno-fetal placental inflammation. DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.

Mots clés: Placental inflammation; Pregnancy; Prematurity

Domaines: Santé publique et épidémiologie

G. Ingrid J. G. Rours, Ronald R. Krijger, Alewijn Ott, Hendrina F. M. Willemse, Ronald Groot, et al.. and placental inflammation in early preterm delivery. European Journal of Epidemiology, 2011, 26 (5), pp.421-428. ⟨10.1007/s10654-011-9569-2⟩. ⟨hal-00682261⟩