Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis

Nicolas Isambert (1) , Maria del Mar Sanchez Duque (1) , Jean-Christophe Plaquevent (2) , Yves Génisson (2) , Jean Rodriguez (1) , Thierry Constantieux (3)

1 STeRéO
2 SPCMIB - Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique
3 ISM2 - Institut des Sciences Moléculaires de Marseille

The efficiency of a chemical synthesis can be nowadays measured, not only by parameters like selectivity and overall yield, but also by its raw material, time, human resources and energy requirements, as well as the toxicity and hazard of the chemicals and the protocols involved. The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. The aim of this tutorial review is to highlight the synergistic effect of the combined use of MCRs and ILs for the development of new eco-compatible methodologies for heterocyclic chemistry.

Mots clés: Multicomponent reaction; Ionic liquids; eco-compatible; heterocycles

Domaines: Chimie organique

Nicolas Isambert, Maria del Mar Sanchez Duque, Jean-Christophe Plaquevent, Yves Génisson, Jean Rodriguez, et al.. Multicomponent reactions and ionic liquids: a perfect synergy for eco-compatible heterocyclic synthesis. Chemical Society Reviews, 2011, 40, pp.1347-1357. ⟨10.1039/c0cs00013b⟩. ⟨hal-00681335⟩