Solvent- and catalyst-Free Three-Component Reaction with beta-Ketoamides for the Stereoselective One-Pot Access to 1,4-Diazepines
Résumé
The stereoselective one-pot synthesis of polysubstituted 1,4-diazepine derivatives has been achieved via a new solvent- and catalyst-free multicomponent domino reaction from b-ketoamides. This green and experimentally simple sequence is conducted from easily accessible achiral starting materials, does not require any harmful reagents, and results in a high increase in molecular com- plexity and diversity. Moreover, water is the only byproduct liber- ated during the reaction.
Origine : Fichiers produits par l'(les) auteur(s)
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