Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles

Sandrine Lamandé-Langle (1) , Mohamed Abarbri (2) , Jérôme Thibonnet (2) , Alain Duchêne (2) , Jean-Luc Parrain (3)

1 SRSMC - Structure et Réactivité des Systèmes Moléculaires Complexes
2 PCMB - EA4244 - Laboratoire Physicochimie des matériaux et des biomolécules
3 STeRéO

Three-component reactions with 3,4-diiodoalk-2-enoic derivatives, primary amines, and terminal alkynes proceeded to give trisubstituted pyrroles in fair to good yields in the presence of palladium and copper catalysts under mild reaction conditions.

Mots clés: multi-component; domino; sonogashira; pyrroles; palladium

Domaines: Chimie organique

Sandrine Lamandé-Langle, Mohamed Abarbri, Jérôme Thibonnet, Alain Duchêne, Jean-Luc Parrain. Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles. Chemical Communications, 2010, 46, pp.5157-5159. ⟨10.1039/c0cc00500b⟩. ⟨hal-00679647⟩