Experience-dependent expression of miR132 regulates ocular dominance plasticity.

Paola Tognini (1) , Elena Putignano (1) , Alessandro Coatti (1) , Tommaso Pizzorusso (1)

1 Neuroscience Institute

MiR132 is a CREB induced microRNA involved in dendritic spine plasticity. We observed that visual experience regulates histone post-translational modifications at a CRE locus important for miR212/132 cluster transcription and miR132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR132 expression in the cortex contralateral to the deprived eye. Counteracting miR132 reduction with infusion of chemically modified miR132 mimic oligonucleotides completely blocked ocular dominance plasticity (ODP).

Mots clés: Plasticity; Sensory Systems; Development; Neurophysiology

Domaines: Neurosciences [q-bio.NC]

Paola Tognini, Elena Putignano, Alessandro Coatti, Tommaso Pizzorusso. Experience-dependent expression of miR132 regulates ocular dominance plasticity.. Nature Neuroscience, 2011, ⟨10.1038/nn.2920⟩. ⟨hal-00676205⟩