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Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2011

Phosphoinositide 3-Kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Résumé

The protein deacetylase SIRT1, and its activator resveratrol, exert beneficial effects on glucose metabolism. Different SIRT1 targets have been identified, including PTP1B, AMPK, FOXO, PGC-1α and IRS2. The latter may underscore a tight link between SIRT1 and insulin signaling components. However, whether SIRT1 has a direct effect on insulin resistance and whether resveratrol acts directly or indirectly in this context is still a matter of controversy and this question has not been addressed in muscle cells.
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hal-00672295 , version 1 (21-02-2012)

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Sara Fröjdö, Christine Durand, Laurent Molin, Andrew L. Carey, Assam El-Osta, et al.. Phosphoinositide 3-Kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Molecular and Cellular Endocrinology, 2011, 335 (2), pp.166. ⟨10.1016/j.mce.2011.01.008⟩. ⟨hal-00672295⟩
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