Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

Ingrid C. Gaemers (1) , Jan M. Stallen (1) , Cindy Kunne (1) , Christian Wallner (2) , Jochem van Werven (2) , Aart Nederveen (2) , Wouter H. Lamers (1)

1 Tytgat Institute for Liver and Intestinal Research
2 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]

The major risk factors for non-alcoholic fatty liver disease (NAFLD) are obesity, insulin resistance and dyslipidemia. The cause for progression from the steatosis stage to the inflammatory condition (non-alcoholic steatohepatitis (NASH)) remains elusive at present,. Aim of this study was to test whether the different stages of NAFLD as well as the associated metabolic abnormalities can be recreated in time in an overfed mouse model and study the mechanisms underlying the transition from steatosis to NASH.

Mots clés: Non-alcoholic fatty liver disease; steatohepatitis; liver; overnutrition; high-fat diet; endoplasmatic reticulum stress; adipose tissue

Domaines: Biochimie, Biologie Moléculaire

Ingrid C. Gaemers, Jan M. Stallen, Cindy Kunne, Christian Wallner, Jochem van Werven, et al.. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (4), pp.447. ⟨10.1016/j.bbadis.2011.01.003⟩. ⟨hal-00670751⟩