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Article Dans Une Revue Biochimica et Biophysica Acta - Molecular Basis of Disease Année : 2011

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

Wenyi Mi
Yuchao Gu
  • Fonction : Auteur
Cuifang Han
  • Fonction : Auteur
Haiyan Liu
  • Fonction : Auteur
Qiong Fan
  • Fonction : Auteur
Xinling Zhang
  • Fonction : Auteur
Qi Cong
  • Fonction : Auteur
Wengong Yu
  • Fonction : Auteur correspondant
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Résumé

O-GlcNAc is a monosaccharide attached to serine or threonine hydroxyl moieties on numerous nuclear and cytoplasmic proteins; O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Although recent studies have shown that O-GlcNAcylation plays essential roles in breast cancer progression, it is also necessary to know whether O-GlcNAcylation is involved in other types of human cancer. In this study, O-GlcNAcylation levels and the expressions of OGT and OGA in human lung and colon cancer tissues were examined by immunohistochemistry analysis. We found that O-GlcNAcylation as well as OGT expression was significantly elevated in the cancer tissues compared with that in the corresponding adjacent tissues. Additionally, the roles of O-GlcNAcylation in the malignancy of lung and colon cancer were investigated . The results showed that O-GlcNAcylation markedly enhanced the anchorage-independent growth of lung and colon cancer cells; O-GlcNAcylation could also enhance lung and colon cancer invasion in a context-dependent manner. All together, this study suggests that O-GlcNAcylation might play important roles in lung and colon cancer formation and progression, and may be a valuable target for diagnosis and therapy of cancer.
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Dates et versions

hal-00670735 , version 1 (16-02-2012)

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Wenyi Mi, Yuchao Gu, Cuifang Han, Haiyan Liu, Qiong Fan, et al.. O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (4), pp.514. ⟨10.1016/j.bbadis.2011.01.009⟩. ⟨hal-00670735⟩

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