Successful management of an MRSA outbreak in a neonatal intensive care unit

N. Heinrich (1, 2) , A. Mueller (2) , P. Bartmann (2) , A. Simon (3) , G. Bierbaum (4) , S. Engelhart (5)

1 Division of Infectious Diseases and Tropical Medicine = Abteilung für infektions und tropenmedizin [Munich, Germany]
2 Children's Hospital Medical Center, Department of Neonatology
3 Department for Paediatric Hematology and Oncology
4 Institute of Medical Microbiology, Immunology, and Parasitology
5 Institute of Hygiene and Public Health

We report an MRSA outbreak in our 25-bed tertiary neonatal intensive care unit (NICU), which was successfully contained. Methods include a retrospective review of patient files, microbiology records and meeting protocols. During the seven months of outbreak, 27 patients and seven health care workers (HCWs) had positive cultures for MRSA. The outbreak was caused by the epidemic Rhine-Hessen strain; cultured isolates were monoclonal. After a sharp increase of the number of new MRSA-cases the installation of an outbreak management team (OMT) and implementation of comprehensive measures (extensive screening and decolonization strategy including orally applied vancomycin, isolation wards, intensive disinfection regimen) successfully terminated the outbreak within one month. Ten (53%) of 19 patients with completed follow-up and all of the HCWs were decolonized successfully. Gastrointestinal colonization was present in 15 of 27 (56%) neonates, and was associated with poor decolonization success (30% vs. 78% in absence of gastrointestinal colonization). A comprehensive outbreak management can terminate an outbreak in a NICU setting within a short time. Thorough screening of nares, throat and especially stool is necessary for correct cohorting. Gastrointestinal decolonization in neonates seems difficult.

Mots clés: Life Sciences

Domaines: Maladies infectieuses

N. Heinrich, A. Mueller, P. Bartmann, A. Simon, G. Bierbaum, et al.. Successful management of an MRSA outbreak in a neonatal intensive care unit. European Journal of Clinical Microbiology and Infectious Diseases, 2011, 30 (7), pp.909-913. ⟨10.1007/s10096-011-1175-4⟩. ⟨hal-00666671⟩