Synthesis of New Tetraethyl(N-alkyl-1-aminoethan-1,1-diyl)bisphosphonates and ESR Analysis of Chemical Exchange of Derived Nitroxides of Acyclic Aminobisphosphonates
Résumé
The synthesis and the full characterization of two new linear bisphosphonates (tetraethyl(N-tertbutyl-1-aminoethan-1,1-diyl)bisphosphonate and tetraethyl(N-secbutyl-1-aminoethan-1,1-diyl)bisphosphonate) and the first analysis of the ESR spectra of the corresponding nitroxides is reported. The preliminary results of theoretical calculations on model compounds suggest a small B0 (in the McConnell equation). The results of bisphosphonate ester and bisphosphonic acid are similar. The discrepancies of P coupling for the diphosphorus compound stems from B2 that is different when the dihedral angle is larger than 90 degree.
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