DNA induced dimerization of a sulfhydryl surfactant in transfection agents studied by ESR spectroscopy

Laura Ciani (1) , Gabriele Candiani (2) , Alessia Frati (1) , Sandra Ristori (1)

1 Department of Chemistry and CSGI
2 Department of Chemistry

Synthetic vectors for gene delivery offer a wide variety of functional derivatization, which can be exploited to increase targeting and transfection efficacy. In this field, redox sensitive agents based on the thiol/disulfide (-SH/-SS-) equilibrium are a class of promising transfectants.

Mots clés: DNA transfection; Electron Spin Resonance; Lipoplexes; Triazine surfactants; Disulfide bond

Laura Ciani, Gabriele Candiani, Alessia Frati, Sandra Ristori. DNA induced dimerization of a sulfhydryl surfactant in transfection agents studied by ESR spectroscopy. Biophysical Chemistry, 2010, 151 (1-2), pp.81. ⟨10.1016/j.bpc.2010.05.010⟩. ⟨hal-00660025⟩