In vitro activity of -chlorotaurine (NCT) in combination with NHCl against

Ursula Fürnkranz (1) , Markus Nagl (2) , Waldemar Gottardi (2) , Michael Duchêne (1) , Horst Aspöck (1) , Julia Walochnik (1)

1 Center for Pathophysiology
2 Department of Hygiene

Trichomoniasis, caused by the protozoan , is usually treated with metronidazole, however resistance is on the rise. In this study, -chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed in vitro within 15min of treatment at a concentration of 55mM (1%), which is well tolerated by human tissue. The activity of NCT was further enhanced by addition of ammonium chloride (NHCl). A combination of 5.5mM (0.1%) NCT plus 19mM (0.1%) NHCl killed 100% of trichomonads within 5min.

Mots clés: Trichomonas vaginalis; Susceptible; N-Chlorotaurine; Oxidant; In vitro

Ursula Fürnkranz, Markus Nagl, Waldemar Gottardi, Michael Duchêne, Horst Aspöck, et al.. In vitro activity of -chlorotaurine (NCT) in combination with NHCl against. International Journal of Antimicrobial Agents, 2011, 37 (2), pp.171. ⟨10.1016/j.ijantimicag.2010.09.006⟩. ⟨hal-00659902⟩