Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype

V. Kuete (1) , S. Alibert-Franco , K.O. Eyong (2) , B. Ngameni (3) , G.N. Folefoc (2) , J.R. Nguemeving (2) , J.G. Tangmouo (2) , G.W. Fotso (2) , J. Komguem (2) , B.M.W. Ouahouo (2) , J.-M. Bolla , Jérome Chevalier , B.T. Ngadjui (2, 3) , A.E. Nkengfack (2) , J.-M. Pagès

1 Faculty of Science
2 Faculty of Science
3 Faculty of Medicine and Biomedical Science

The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM () efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.

Mots clés: Terpenoids; Alkaloids; Phenolics; Multidrug resistance; Efflux pump inhibitor; Antibacterial activities

V. Kuete, S. Alibert-Franco, K.O. Eyong, B. Ngameni, G.N. Folefoc, et al.. Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype. International Journal of Antimicrobial Agents, 2011, 37 (2), pp.156. ⟨10.1016/j.ijantimicag.2010.10.020⟩. ⟨hal-00659899⟩