Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Periodontology Année : 2011

Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig

Philipp Stockmann
  • Fonction : Auteur
  • PersonId : 909143
Kerstin Amann
  • Fonction : Auteur
  • PersonId : 909141
Philipp Metzler
  • Fonction : Auteur
  • PersonId : 917490
Rainer Lutz
  • Fonction : Auteur
  • PersonId : 917491
Tobias Moest
  • Fonction : Auteur
  • PersonId : 917492
Karl Andreas Schlegel
  • Fonction : Auteur
  • PersonId : 909144

Résumé

Aim: Diabetes mellitus is classified as a relative contraindication for implant treatment, and higher failure rates have been seen in diabetic patients. The aim of the present study was to investigate the effect of diabetes on peri-implant bone formation in an animal model of human bone repair. Materials and Methods: Diabetes was induced by intravenous application of streptozotocin (90 mg/kg) in 15 domestic pigs. Implants were placed after significant histopathological changes in the hard and soft tissues were verified. The bone-implant-contact (BIC), peri-implant bone mineral density (BMD), and expression of collagen type-I and osteocalcin proteins were qualitatively evaluated 4 and 12 weeks after implantation. Fifteen animals served as healthy controls. Results: Diabetes caused pathological changes in the soft and hard tissues. The BIC and BMD were significantly reduced in the diabetic group after 4 and 12 weeks. Collagen type-I was increased in the diabetic group at both time points, whereas osteocalcin was reduced in the diabetic group. Conclusions: Poorly controlled diabetes negatively affects peri-implant bone formation and bone mineralization. These findings have to be taken into consideration for diabetic patients with an indication for implant therapy.

Mots clés

Fichier principal
Vignette du fichier
PEER_stage2_10.1111%2Fj.1600-051X.2011.01746.x.pdf (1.47 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00659529 , version 1 (13-01-2012)

Identifiants

Citer

Cornelius von Wilmowsky, Philipp Stockmann, Igor Alexander Harsch, Kerstin Amann, Philipp Metzler, et al.. Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig. Journal of Clinical Periodontology, 2011, 38 (8), pp.771. ⟨10.1111/j.1600-051X.2011.01746.x⟩. ⟨hal-00659529⟩

Collections

PEER
284 Consultations
547 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More