Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes.

Jacques Sainte-Marie , M. Vignes (1, 2, 3) , M. Vidal , J. R. Philippot , A. Bienvenüe (4)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 PC - Plasticité cérébrale
3 Neurobiologie de l'audition-plasticité synaptique
4 IBCP - Institut de biologie et chimie des protéines [Lyon]

We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L2C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.

Domaines: Neurosciences [q-bio.NC]

Jacques Sainte-Marie, M. Vignes, M. Vidal, J. R. Philippot, A. Bienvenüe. Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes.. FEBS Letters, 1990, 262 (1), pp.13-6. ⟨10.1016/0014-5793(90)80141-5⟩. ⟨hal-00659475⟩