The Wnt/beta-catenin pathway in adrenocortical development and cancer

Abeer El Wakil (1, 2) , Enzo Lalli (1, 2)

1 IPMC - Institut de pharmacologie moléculaire et cellulaire
2 UNS - Université Nice Sophia Antipolis (1965 - 2019)

Signaling by the Wnt family of secreted glycolipoproteins plays key roles in embryonic development of organisms ranging from nematodes to mammals and is also implicated in several types of human cancers. Canonical Wnt signaling functions by regulating the translocation of β-catenin to the nucleus, where it controls key gene expression programs through interaction with Tcf/Lef and other families of transcription factors. Wnts can also act through non-canonical pathways that do not involve β-catenin activation, but implicate small GTPases/JNK kinase and intracellular calcium.

Mots clés: Adrenal cortex; Wnt; β-catenin; development; cancer

Abeer El Wakil, Enzo Lalli. The Wnt/beta-catenin pathway in adrenocortical development and cancer. Molecular and Cellular Endocrinology, 2010, 332 (1-2), pp.32. ⟨10.1016/j.mce.2010.11.014⟩. ⟨hal-00654958⟩