NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, "Cold" Analogs of PET/SPECT Tracers

Qiuju Zhou (1) , Céline Henoumont (1) , Luce Vander Elst (1) , Sophie Laurent (1) , Robert N Muller (1, 2)

1 General, Organic and Biomedical Chemistry
2 Center for Microscopy and Molecular Imaging (CMMI), Académie Wallonie-Bruxelles

Ga-complexes are widely used as radiopharmaceuticals for PET or SPECT imaging and as therapeutic agents. At physiological pH, free gallium(III) ions can stably exist as soluble gallate [Ga(OH)4]−, a nephrotoxic compound whose presence should be avoided. Any Ga-complex, therefore, should be carefully checked for the absence of gallate before use. Here we show that 71Ga NMR is a useful tool to rapidly detect the presence of gallate in aqueous solutions of Ga-complexes and to follow the purification steps of the Ga-complex solutions.

Mots clés: Physical Sciences

Qiuju Zhou, Céline Henoumont, Luce Vander Elst, Sophie Laurent, Robert N Muller. NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga-complexes, "Cold" Analogs of PET/SPECT Tracers. Contrast Media and Molecular Imaging, 2011, 6 (3), pp.165. ⟨10.1002/cmmi.441⟩. ⟨hal-00654800⟩