The CRP Genotype, Serum Levels and Lung Function in men: The Caerphilly Prospective Study
Résumé
Background Systemic C-reactive protein (CRP) has been associated with impaired lung function. A causal relationship would increase the value of CRP as both a diagnostic and therapeutic tool. We assessed the association between lung function parameters, circulating CRP and CRP polymorphisms using Mendelian Randomisation in efforts to attribute causality to known associations. Methods Spirometric parameters of FEV1 and FVC were determined in 2173 men participating in the Caerphilly Prospective Study. Lung function measures on 1021 participants were available at follow up (16.8 mean yrs later). Serum CRP level was measured at baseline and three CRP polymorphisms were analysed. Haplotype analysis was performed. Results Serum CRP levels at baseline were inversely associated with contemporaneous FEV1 and FVC as well as at follow-up (p<0.001) even after adjustment for conventional confounders. Serum CRP was associated with FEV1 decline, p=0.04. All three CRP polymorphisms (rs1800947, rs1130864, rs1205) predicted serum CRP; however there were no clear associations of the polymorphisms or haplotypes with lung function or with lung function decline. Conclusion Serum CRP was associated with lung function cross-sectionally however CRP polymorphisms were not associated with lung function or decline, suggesting that the CRP-lung function relationship is either due to reverse causality, unmeasured confounding factor or only has modest causal effect.
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