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Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2010

Severe spp. infections: new insights into natural immunity

Résumé

Invasive infections caused by spp. are associated with high mortality. Colonization by spp. and the capacity of the host to recognize them as potential pathogens are essential steps in the development of these infections. The major pathogen-associated molecular patterns of are mannoproteins, glucans and chitins, which are recognized by C-type lectin pattern recognition receptors such as the mannose receptor, dectin-1 and dectin-2. By the secretion of proteases and toxins, and the formation of hyphae and biofilms, spp. are able to enhance their virulence and pathogenicity. Studies in patients with relatively rare immunodeficiencies, such as dectin-1 deficiency, CARD9 deficiency, chronic mucocutaneous candidiasis, hyper-IgE/Job's syndrome and chronic granulomatous disease, have shown the role of dectin-1 and its signalling pathway, which involves interleukins17 and 22, defensins and phagocytic cells, in defence against . These studies also provide insights into how acquired risk factors for fungal infection operate, and may lead to new approaches for immunotherapy.
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Dates et versions

hal-00650374 , version 1 (10-12-2011)

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Jos W.M. van Der Meer, Frank L. van de Veerdonk, Leo A.B. Joosten, Bart-Jan Kullberg, Mihai G. Netea. Severe spp. infections: new insights into natural immunity. International Journal of Antimicrobial Agents, 2010, 36, ⟨10.1016/j.ijantimicag.2010.11.013⟩. ⟨hal-00650374⟩

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