Improved enzymatic production of phenolated acylglycerols through alkyl phenolate intermediates

Zhiyong Yang (1) , Vivian Feddern (2) , Marianne Glasius (3) , Zheng Guo (1) , Xuebing Xu (1)

1 Department of Molecular Biology
2 School of Chemistry and Food, Laboratory of Food Science
3 Department of Chemistry

A novel approach is reported for the synthesis of dihydrocaffoylated glycerols that consists of two steps: enzymatic synthesis of octyl dihydrocaffeate (as a synthetic intermediate) from octanol and dihydrocaffeic acid, and enzymatic interesterification of triacylglycerols with octyl dihydrocaffeate. Due to the good compatibility of the intermediate with triacylglycerols, an improved volumetric productivity [147 mol h(kg Novozym 435)] and high enzyme specific activity [up to 9.6 μmol min(g Novozym 435)] have been obtained.

Mots clés: Alkyl phenolate; Dihydrocaffeic acid; Lipase; Phenolic acids; Interesterification

Zhiyong Yang, Vivian Feddern, Marianne Glasius, Zheng Guo, Xuebing Xu. Improved enzymatic production of phenolated acylglycerols through alkyl phenolate intermediates. Biotechnology Letters, 2010, 33 (4), pp.673-679. ⟨10.1007/s10529-010-0486-3⟩. ⟨hal-00646926⟩