Endpoints in pediatric pain studies

Monique Dijk (1) , Ilse Ceelie (1) , Dick Tibboel (1)

1 Intensive Care and Department of Pediatric Surgery

Assessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analgesic consumption, adverse effects, and long-term effects] in studies on the effects of analgesic drugs. Here, we review current and promising new endpoints used in pediatric pain assessment studies.

Mots clés: Pain; Assessment; Pharmacokinetics; Pharmacodynamics; Long-term outcome

Monique Dijk, Ilse Ceelie, Dick Tibboel. Endpoints in pediatric pain studies. European Journal of Clinical Pharmacology, 2010, 67 (S1), pp.61-66. ⟨10.1007/s00228-010-0947-6⟩. ⟨hal-00644273⟩