Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomized open-label study

Panagiotis Anagnostis (1) , Despina Selalmatzidou (2) , Stergios Polyzos (3) , Athanasios Panagiotou (2) , Aristidis Slavakis (4) , Aikaterini Panagiotidou (4) , Vasilios Athyros (5) , Asterios Karagiannis (6) , Dimitri P. Mikhailidis (7) , Marina Kita (2)

1 Endocrinology Clinic
2 Endocrinology Clinic
3 Second Medical Clinic
4 Department of Biochemistry
5 2nd Propedeutic Department of Internal Medicine
6 Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital
7 Chemical Pathology

Aims: The impact of statins on glucose metabolism and adipokines remains controversial. We compared the effects of rosuvastatin and atorvastatin on glucose homeostasis, insulin sensitivity (IS), adiponectin and leptin levels as well as systemic inflammation in non-diabetic patients with dyslipidaemia. Methods: Thirty-six patients were randomly assigned to receive 10 mg/day of rosuvastatin (n=18) or 20 mg/day of atorvastatin (n=18) for 12 weeks. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TG), fasting plasma glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), quantitative IS check index (QUICKI), adiponectin, leptin and high-sensitivity C-reactive protein (hsCRP) were measured at baseline and after 4 and 12 weeks. Results: Both statins significantly lowered TC, LDL-C, non-HDL-C and TG compared with baseline. Only rosuvastatin caused a significant reduction in insulin and HOMA-IR levels (-35%, p=0.005 and -33%, p=0.011, respectively) and a significant increase in QUICKI (+11%, p=0.003) at 12 weeks. In terms of adipokines and hsCRP, no difference was observed after 4 and 12 weeks of treatment with either statin. Conclusions: Rosuvastatin compared with atorvastatin resulted in significant improvements in IS indices. No significant changes in adiponectin, leptin or hsCRP levels were observed at 4 and 12 weeks of treatment with either statin.

Mots clés: Medicine

Panagiotis Anagnostis, Despina Selalmatzidou, Stergios Polyzos, Athanasios Panagiotou, Aristidis Slavakis, et al.. Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomized open-label study. International Journal of Clinical Practice, 2011, 65 (6), pp.679. ⟨10.1111/j.1742-1241.2011.02655.x⟩. ⟨hal-00640468⟩