In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: results of the COMPACT Asia-Pacific Study

K.J. Christiansen (1) , M. Ip (2) , H.B. Ker (3) , M. Mendoza (4) , L. Hsu (5) , P. Kiratisin (6) , A. Chongthaleong (7) , I.S. Redjeki , A. Quintana , R. Flamm , J. Garcia , M. Cassettari (8) , D. Cooper (8) , P. Okolo (8) , I. Morrissey (8)

1 Royal Perth Hospital
2 CUHK - The Chinese University of Hong Kong [Hong Kong]
3 Hospital Raja Permaisuri Bainun
4 Philippine General Hospital
5 National University Hospital
6 Mahidol University [Bangkok]
7 King Chulalongkorn Memorial Hospital
8 Quotient Bioresearch Ltd.

The Comparative Activity of Carbapenems Testing (COMPACT) Study was designed to determine the in vitro potency of doripenem compared with imipenem and meropenem against a large number of contemporary Gram-negative pathogens from more than 100 centres across Europe and the Asia-Pacific region and to assess the reliability of Etest methodology for doripenem minimum inhibitory concentration (MIC) determination against these pathogens. Data from eight countries within the Asia-Pacific region, which collected 1612 bacterial isolates, are presented here. Etest methodology was found to be a reliable method for MIC determination. Doripenem showed in vitro activity similar to or better than meropenem and at least four-fold better than imipenem against Enterobacteriaceae. Against , doripenem was also the most active of the three carbapenems in vitro. However, in vitro results do not necessary correlate with clinical outcome.

Mots clés: Carbapenem; Doripenem; Enterobacteriaceae; Gram-negative; Surveillance

K.J. Christiansen, M. Ip, H.B. Ker, M. Mendoza, L. Hsu, et al.. In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: results of the COMPACT Asia-Pacific Study. International Journal of Antimicrobial Agents, 2010, 36 (6), pp.501. ⟨10.1016/j.ijantimicag.2010.08.002⟩. ⟨hal-00640449⟩