The association of lifetime alcohol use with measures of abdominal and general adiposity in a large-scale European cohort

Manuela M Bergmann (1) , Madlen Schütze (1) , Annika Steffen (1) , Heiner Boeing (1) , Jytte Halkjær (1) , Anne Tjonneland (1) , Noémie Travier (1) , Antonio Agudo (1) , Nadia Slimani (1) , Sabina Rinaldi (1) , Teresa Norat (1) , Dora Romaguera (1) , Sabine Rohrmann (1) , Rudolf Kaaks (1) , Marianne Uhre Jacobsen (1) , Prof. Kim Overvad (1) , Ulf Ekelund (1) , Elizabeth Spencer (1) , Laudina Rodríguez (1) , Maria J Sánchez (1) , Miren Dorronsoro (1) , Aurelio Barricarte (1) , Maria Dolores Chirlaque (1) , Philippos Orfanos (1) , Androniki Naska (1) , Antonia Trichopoulou (1) , Domenico Palli (1) , Sara Grioni (1) , Paolo Vineis (1) , Salvatore Panico (1) , Rosario Tumino (1) , E Riboli (1) , Nick Wareham (1) , Bas Bueno de Mesquita (1) , Anne May (1) , P. Peeters (1)

1 Epidemiology

Background: The relation between lifetime use of alcohol and measures of abdominal and general adiposity is unknown. Methods: Among 99,381 men and 158,796 women of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, means of waist circumference (WC), waist-to-hip-ratio (WHR) and body mass index (BMI), and odds ratios (OR) for a larger WC than predicted for a given BMI (WClp=positive residuals of gender specific linear regression of BMI on WC) across categories of average lifetime use of alcohol (total, from wine and from beer) were calculated, all adjusted for socio-demographic, lifestyle and health factors. Results: WC, WHR and BMI in men using lifetime ≤6g/d alcohol were 95.1cm, 0.942 and 27.3kg/m2, and 96.2cm, 0.961 and 28.3kg/m2 when using >96g/d. WC and WHR in women was 83.2cm and 0.813 for ≤6g/d, and 84.6cm and 0.830 for >60g/d while BMI deviated only slightly with the lowest BMI (26.7kg/m2) observed for >6-24g/d. Compared to ≤6g/d, OR for a WClp in both genders increased steadily across categories of alcohol use (up to 1.40 (95% confidence interval 1.32, 1.49) in men using >60g/d and 1.63 (1.54, 1.73) in women using >24g/d); though increase was higher for alcohol from beer than from wine (p for difference between beer and wine<0.001 (men) and =0.002 (women)). Conclusion: Lifetime alcohol use is positively related to abdominal and general adiposity in men, possibly following the male weight gain pattern; in women it is positively related only to abdominal adiposity. In this context, beer may contribute additionally to abdominal adiposity.

Mots clés: alcohol; abdominal adiposity; waist circumference; body mass index; multicentric epidemiological study

Manuela M Bergmann, Madlen Schütze, Annika Steffen, Heiner Boeing, Jytte Halkjær, et al.. The association of lifetime alcohol use with measures of abdominal and general adiposity in a large-scale European cohort. European Journal of Clinical Nutrition, 2011, ⟨10.1038/ejcn.2011.70⟩. ⟨hal-00640222⟩