Correlation between Scanning Laser Polarimetry with and without Enhanced Corneal Compensation and High Definition Optical Coherence Tomography in Normal and Glaucomatous Eyes

Javier Benitez-Del-Castillo (1) , Antonio Martinez (2) , Teresa Regi (1)

1 Glaucoma
2 Clinical research department

Purpose: To assess the relationship between high-definition optical coherence tomography (HD-OCT) and scanning laser polarimetry (SLP) with variable (VCC) and enhance (ECC) corneal compensation in measuring peripapillary retinal nerve fiber layer (RNFL) thickness in healthy eyes and those with early-to-moderate glaucomatous VF loss. Methods: Healthy volunteers and patients with glaucoma who met the eligibility criteria were enrolled in this prospective, cross-sectional, and observational study. Subjects underwent complete ophthalmologic examination, automated perimetry, SLP-ECC, SLP-VCC, and HD-OCT. SLP parameters were recalculated in 90 degrees segments (quadrants) in the calculation circle to be compared. Pearson correlation coefficients and Lin's concordance correlation coefficients were calculated. P-values less than 0.05 were considered statistically significant. Results: Fifty-five normal volunteers (mean age 59.1 years) and 33 patients with glaucoma (mean age 63.8 years) were enrolled. In the glaucoma group, 18 patients (54.5 %) had MD ≥ -6.0 decibels (early glaucoma) and 15 patients (45.4%) had MD between -6.01 and -12.0 decibels (moderate glaucoma). The best correlation between HD-OCT and SLP was found in the superior quadrant thickness, r=0.74 (0.62 to 0.82) (p< 0.0001) with SLP-VCC and in the average thickness, r= 0.80 (0.71 to 0.86) (p< 0.0001) and the superior quadrant thickness r= 0.80 (0.71 to 0.87) (p< 0.0001) with SLP-ECC. Concordance correlation coefficients obtained for every parameter in our study between HD-OCT and SLP-VCC and between HD-OCT and SLP-ECC were poor. Conclusions: Our results suggest that HD-OCT parameters of RNFL thickness are significantly higher than SLP-VCC and SLP-ECC parameters, and therefore those thickness values are not interchangeable. HD-OCT and SLP methods are well correlated but concordance is poor. The difference plots show a lack of agreement that changes as a proportion of the mean.

Mots clés: Medicine

Javier Benitez-Del-Castillo, Antonio Martinez, Teresa Regi. Correlation between Scanning Laser Polarimetry with and without Enhanced Corneal Compensation and High Definition Optical Coherence Tomography in Normal and Glaucomatous Eyes. International Journal of Clinical Practice, 2011, 65 (7), pp.807. ⟨10.1111/j.1742-1241.2011.02649.x⟩. ⟨hal-00637820⟩