The Use of the SAEM Algorithm in MONOLIX Software for Estimation of Population Pharmacokinetic-Pharmacodynamic-Viral Dynamics Parameters of Maraviroc in Asymptomatic HIV Subjects - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Pharmacokinetics and Pharmacodynamics Année : 2010

The Use of the SAEM Algorithm in MONOLIX Software for Estimation of Population Pharmacokinetic-Pharmacodynamic-Viral Dynamics Parameters of Maraviroc in Asymptomatic HIV Subjects

Résumé

Using simulated viral load data for a given maraviroc monotherapy study design, the feasibility of different algorithms to perform parameter estimation for a pharmacokinetic-pharmacodynamic-viral dynamics (PKPD-VD) model was assessed. The assessed algorithms are the first-order conditional estimation method with interaction (FOCEI) implemented in NONMEM VI and the SAEM algorithm implemented in MONOLIX version 2.4.
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Dates et versions

hal-00637403 , version 1 (01-11-2011)

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Phylinda Chan, Philippe Jacqmin, Marc Lavielle, Lynn Mcfadyen, Barry Weatherley. The Use of the SAEM Algorithm in MONOLIX Software for Estimation of Population Pharmacokinetic-Pharmacodynamic-Viral Dynamics Parameters of Maraviroc in Asymptomatic HIV Subjects. Journal of Pharmacokinetics and Pharmacodynamics, 2010, 38 (1), pp.41-61. ⟨10.1007/s10928-010-9175-z⟩. ⟨hal-00637403⟩

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